Quantitative Aspects of Chemical Pharmacology Chemical Ideas in Drug Action with Numerical Examples /
| Autor principal: | |
|---|---|
| Autor Corporativo: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
New York, NY :
Springer US : Imprint: Springer,
1980.
|
| Edición: | 1st ed. 1980. |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1007/978-1-4684-8332-1 |
Tabla de Contenidos:
- 1. Measuring Drug Activity
- Measuring the Effects of Drugs: ‘Responses’
- Assessing Biological Activity
- Application of Bioassay Methods to the Comparison of Drugs
- Types of Drug Action
- 2. Physicochemical Problems
- Rates of Reaction and Positions of Equilibrium
- Solubility
- Volume of Dilution
- Rate of Removal
- Rate of Absorption
- Partition Coefficients and Crossing Membranes
- Relations between Reaction Rates and Equilibrium Constants
- 3. The Size and Shape of Molecules
- Size: Molal Volumes and Apparent Molal Volumes
- Shape
- Isomerism
- Optical Rotation
- Stereochemical Purity and Biological Activity
- Description of the Arrangements of Groups about an Asymmetric Carbon Atom
- Preferred Conformations
- 4. Chemical Processes where Size and Shape are Important
- Adsorption
- Adsorption of Two Species
- Enzyme and Substrate
- The Need for Other Models
- Agonists and Receptors
- Rate Theory
- Desensitisation of Receptors
- Forces between Drug and Receptor
- 5. The Prediction of Drug Activity
- Nonspecific Activity
- Homologous Series
- Biological Activity and Chemical Properties: the Ideas of Hansch
- Is Affinity Predictable?
- Conclusion
- Appendix: Line-fitting by the method of least-squares
- Answers to Examples.