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02722nam a22003015i 4500 |
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978-1-59259-394-1 |
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20190618131844.0 |
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cr nn 008mamaa |
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100301s2003 xxu| s |||| 0|eng d |
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|a 9781592593941
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| 024 |
7 |
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|a 10.1385/1592593941
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Protein Misfolding and Disease
|c edited by Peter Bross, Niels Gregersen.
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| 250 |
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|a 1st ed. 2003.
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| 260 |
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|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2003.
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| 300 |
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|a XV, 318 p.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
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|a Methods in Molecular Biology,
|v 232
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| 505 |
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|a General Concepts and Models -- Protein Misfolding, Aggregation, and Degradation in Disease -- Basic Introduction to In Vivo Protein Folding and Its Defects -- Cystic Fibrosis -- ?1-Antitrypsin Deficiency -- Parkinson’s Disease -- Aberrant Protein Folding as the Molecular Basis of Cancer -- Yeast as a Model System to Investigate Protein Conformational Diseases -- General Methods -- Expression of Recombinant Proteins -- Expression in E. coli Systems -- Protein Expression in Yeasts -- Site-Directed Mutagenesis -- Pulse-Chase Labeling Techniques for the Analysis of Protein Maturation and Degradation -- Techniques in Conformational Disease Research -- Detection of Aggregates and Protein Inclusions by Staining of Tissues -- Study of Mutant Proteins With Folding Defects in Cultured Patient Cells -- E. coli Expression System for Identifying Folding Mutations of Human Adenosine Deaminase -- Characterization of Overexpressed Mutant Proteins in Mammalian Cells -- Investigation of Unfolded-Protein Response in Cells Expressing Familial Alzheimer's Disease-Linked Presenilin Variants -- Huntingtin Fragments Form Aggresome-Like Inclusion Bodies in Mammalian Cells -- Application of Chemical Chaperones to the Rescue of Folding Defects -- Analysis of Defective Subunit Interactions Using the Two-Hybrid System -- Investigation of Folding and Degradation of In Vitro Synthesized Mutant Proteins in the Cytosol -- Investigation of Folding and Degradation of In Vitro Synthesized Mutant Proteins in Microsomes -- Investigation of Folding and Degradation of In Vitro Synthesized Mutant Proteins in Mitochondria -- Investigation of Folding and Degradation of Mutant Proteins Synthesized in Semipermeabilized Cells.
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| 650 |
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|a Biochemistry.
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| 650 |
1 |
4 |
|a Biochemistry, general.
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| 700 |
1 |
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|a Bross, Peter.
|e editor.
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| 700 |
1 |
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|a Gregersen, Niels.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 856 |
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|u https://doi.org/10.1385/1592593941
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