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02642nam a22003015i 4500 |
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978-1-59259-800-7 |
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20190618031339.0 |
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cr nn 008mamaa |
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100301s2004 xxu| s |||| 0|eng d |
| 020 |
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|a 9781592598007
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| 024 |
7 |
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|a 10.1385/1592598005
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del Tecnológico de Costa Rica
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| 245 |
1 |
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|a Optimization in Drug Discovery
|c edited by Zhengyin Yan, Gary W. Caldwell.
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| 250 |
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|a 1st ed. 2004.
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| 260 |
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|a Totowa, NJ :
|b Humana Press :
|b Imprint: Humana,
|c 2004.
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| 300 |
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|a XVI, 420 p.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in Pharmacology and Toxicology,
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| 505 |
0 |
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|a pKa, Solubility, and Lipophilicity -- Use of Caco-2 Cell Monolayers to Study Drug Absorption and Metabolism -- Absorption Screening Using the PAMPA Approach -- In Situ Single-Pass Perfused Rat Intestinal Model for Absorption and Metabolism -- In Vitro Permeation Study With Bovine Brain Microvessel Endothelial Cells -- An Enzymatic Microplate Assay for Testing P-Glycoprotein Substrates and Inhibitors -- Evaluation of Drug-Transporter Interactions Using In Vitro Cell Models -- Plasma Protein-Binding Methods in Drug Discovery -- Isothermal Titration Calorimetry Characterization of Drug-Binding Energetics to Blood Proteins -- Metabolic Stability Assessed by Liver Microsomes and Hepatocytes -- In Vitro Drug Metabolite Profiling Using Hepatic S9 and Human Liver Microsomes -- In Vitro Identification of UDP-Glucuronosyltransferases (UGTs) Involved in Drug Metabolism -- In Vitro CYP Induction in Human Hepatocytes -- High-Throughput Screening of Human Cytochrome P450 Inhibitors Using Fluorometric Substrates -- Evaluation of Cytochrome P450 Inhibition in Human Liver Microsomes -- Identification of CYP Mechanism-Based Inhibitors -- Detection of DNA Adducts by 32P-Postlabeling Analysis -- Covalent DNA Adduct Formation Mediated by Cytochrome P450 -- Application of In Vitro Comet Assay for Genotoxicity Testing -- Assessing DNA Damage Using a Reporter Gene System -- Improvement of the Ames Test Using Human Liver S9 Preparation -- Screening for Chemical Mutagens Using the Mouse Lymphoma Assay -- A High-Throughput Binding Assay for HERG -- In Vitro Drug Metabolism -- In Vitro Screening Assay of the Reactivity of Acyl Glucuronides.
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| 650 |
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|a Pharmacy.
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| 650 |
1 |
4 |
|a Pharmacy.
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| 700 |
1 |
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|a Yan, Zhengyin.
|e editor.
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| 700 |
1 |
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|a Caldwell, Gary W.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 856 |
4 |
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|u https://doi.org/10.1385/1592598005
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