Optimization in Drug Discovery
| Autor Corporativo: | |
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| Otros Autores: | , |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2004.
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| Edición: | 1st ed. 2004. |
| Colección: | Methods in Pharmacology and Toxicology,
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| Materias: | |
| Acceso en línea: | https://doi.org/10.1385/1592598005 |
Tabla de Contenidos:
- pKa, Solubility, and Lipophilicity
- Use of Caco-2 Cell Monolayers to Study Drug Absorption and Metabolism
- Absorption Screening Using the PAMPA Approach
- In Situ Single-Pass Perfused Rat Intestinal Model for Absorption and Metabolism
- In Vitro Permeation Study With Bovine Brain Microvessel Endothelial Cells
- An Enzymatic Microplate Assay for Testing P-Glycoprotein Substrates and Inhibitors
- Evaluation of Drug-Transporter Interactions Using In Vitro Cell Models
- Plasma Protein-Binding Methods in Drug Discovery
- Isothermal Titration Calorimetry Characterization of Drug-Binding Energetics to Blood Proteins
- Metabolic Stability Assessed by Liver Microsomes and Hepatocytes
- In Vitro Drug Metabolite Profiling Using Hepatic S9 and Human Liver Microsomes
- In Vitro Identification of UDP-Glucuronosyltransferases (UGTs) Involved in Drug Metabolism
- In Vitro CYP Induction in Human Hepatocytes
- High-Throughput Screening of Human Cytochrome P450 Inhibitors Using Fluorometric Substrates
- Evaluation of Cytochrome P450 Inhibition in Human Liver Microsomes
- Identification of CYP Mechanism-Based Inhibitors
- Detection of DNA Adducts by 32P-Postlabeling Analysis
- Covalent DNA Adduct Formation Mediated by Cytochrome P450
- Application of In Vitro Comet Assay for Genotoxicity Testing
- Assessing DNA Damage Using a Reporter Gene System
- Improvement of the Ames Test Using Human Liver S9 Preparation
- Screening for Chemical Mutagens Using the Mouse Lymphoma Assay
- A High-Throughput Binding Assay for HERG
- In Vitro Drug Metabolism
- In Vitro Screening Assay of the Reactivity of Acyl Glucuronides.