|
|
|
|
| LEADER |
02307nam a22003495i 4500 |
| 001 |
978-3-540-73709-4 |
| 005 |
20191027161018.0 |
| 007 |
cr nn 008mamaa |
| 008 |
100301s2008 gw | s |||| 0|eng d |
| 020 |
|
|
|a 9783540737094
|
| 024 |
7 |
|
|a 10.1007/978-3-540-73709-4
|2 doi
|
| 040 |
|
|
|a Sistema de Bibliotecas del Tecnológico de Costa Rica
|
| 245 |
1 |
0 |
|a Telomeres and Telomerase in Aging, Disease, and Cancer
|b Molecular Mechanisms of Adult Stem Cell Ageing /
|c edited by K. Lenhard Rudolph.
|
| 250 |
|
|
|a 1st ed. 2008.
|
| 260 |
# |
# |
|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 2008.
|
| 300 |
|
|
|a XIV, 330 p. 64 illus., 25 illus. in color.
|b online resource.
|
| 336 |
|
|
|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b c
|2 rdamedia
|
| 338 |
|
|
|a online resource
|b cr
|2 rdacarrier
|
| 505 |
0 |
|
|a Telomere Shortening and Ageing -- Cellular versus Organismal Aging -- Telomere-Induced Senescence of Primary Cells -- Telomeres, Senescence, Oxidative Stress, and Heterogeneity -- Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres -- Telomerase Mutations and Premature Ageing in Humans -- Telomerase, Telomeres, and Stem Cell Aging -- Mechanisms of Stem Cell Ageing -- Senescence Signatures of Human Hematopoietic Stem Cells -- Telomere Shortening Induces Cell Intrinsic Checkpoints and Environmental Alterations Limiting Adult Stem Cell Function -- p16INK4a and Stem Cell Ageing: A Telomere-Independent Process? -- Telomerase as a Potential Regulator of Tissue Progenitor Cells -- Telomeres, DNA Damage and Cancer -- Telomere Shortening and Telomerase Activation during Cancer Formation -- Telomere Binding Proteins and Disease -- Therapeutic Targets -- Targeting Telomerase: Therapeutic Options for Cancer Treatment -- Werner Syndrome, Telomeres, and Stress Signaling: Implications for Future Therapies?.
|
| 650 |
|
0 |
|a Human genetics.
|
| 650 |
|
0 |
|a Biochemistry.
|
| 650 |
|
0 |
|a Cell biology.
|
| 650 |
|
0 |
|a Cancer research.
|
| 650 |
1 |
4 |
|a Human Genetics.
|
| 650 |
2 |
4 |
|a Biochemistry, general.
|
| 650 |
2 |
4 |
|a Cell Biology.
|
| 650 |
2 |
4 |
|a Cancer Research.
|
| 700 |
1 |
|
|a Rudolph, K. Lenhard.
|e editor.
|
| 710 |
2 |
|
|a SpringerLink (Online service)
|
| 773 |
0 |
|
|t Springer eBooks
|
| 856 |
4 |
0 |
|u https://doi.org/10.1007/978-3-540-73709-4
|