The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies Age-Associated (Geriatric) Pathology: Its Impact on Long-Term Toxicity Studies /

The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies Age-Associated (Geriatric) Pathology: Its Impact on Long-Term Toxicity Studies /

Detalles Bibliográficos
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Grice, H.C. (Editor )
Formato: eBook
Lenguaje:English
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1984.
Edición:1st ed. 1984.
Colección:Current Issues in Toxicology,
Materias:
Pharmacology.
Oncology  .
Pharmacy.
Pharmacology/Toxicology.
Oncology.
Acceso en línea:https://doi.org/10.1007/978-3-642-49293-8
Tabla de Contenidos:
  • The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies
  • I. Introduction
  • II. Factors Relating to the Dose Selection
  • III. Principles for Dose Selection
  • IV. Evaluation and Interpretation of Experimental Findings
  • V. Recommendations for Future Research on Dose Selection
  • VI. Summary
  • VII. Glossary of Terms — As They Pertain to Toxicology
  • VIII. References
  • Age-Associated (Geriatric) Pathology: Its Impact on Long-Term Toxicity Studies
  • I. Introduction
  • II. Types of Long-Term Tests
  • III. Factors Related to the Aging Process that Influence the Design and Conduct of Long-Term Rodent Studies
  • IV. Age-Associated Diseases: How They Complicate Long-Term Toxicity Studies
  • V. Effect of Aging on Drug Metabolism
  • VI. Duration of Long-Term Studies
  • VII. Cost of Conducting Toxicity Studies with Durations of 18, 24, or 30 Months
  • VIII. Conclusions
  • IX. Areas in Need of Future Research
  • X. Summary
  • XI. References.

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