The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies Age-Associated (Geriatric) Pathology: Its Impact on Long-Term Toxicity Studies /

Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Grice, H.C. (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 1984.
Edition:1st ed. 1984.
Series:Current Issues in Toxicology,
Subjects:
Online Access:https://doi.org/10.1007/978-3-642-49293-8
Table of Contents:
  • The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies
  • I. Introduction
  • II. Factors Relating to the Dose Selection
  • III. Principles for Dose Selection
  • IV. Evaluation and Interpretation of Experimental Findings
  • V. Recommendations for Future Research on Dose Selection
  • VI. Summary
  • VII. Glossary of Terms - As They Pertain to Toxicology
  • VIII. References
  • Age-Associated (Geriatric) Pathology: Its Impact on Long-Term Toxicity Studies
  • I. Introduction
  • II. Types of Long-Term Tests
  • III. Factors Related to the Aging Process that Influence the Design and Conduct of Long-Term Rodent Studies
  • IV. Age-Associated Diseases: How They Complicate Long-Term Toxicity Studies
  • V. Effect of Aging on Drug Metabolism
  • VI. Duration of Long-Term Studies
  • VII. Cost of Conducting Toxicity Studies with Durations of 18, 24, or 30 Months
  • VIII. Conclusions
  • IX. Areas in Need of Future Research
  • X. Summary
  • XI. References.