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02033nam a22003015i 4500 |
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978-3-642-60998-5 |
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20191027041754.0 |
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cr nn 008mamaa |
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121227s1996 gw | s |||| 0|eng d |
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|a 9783642609985
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7 |
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|a 10.1007/978-3-642-60998-5
|2 doi
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| 040 |
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|a Sistema de Bibliotecas del TEC
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| 100 |
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|a Breuel, Hans-Peter.
|e author.
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|a Clinical Pharmacology in the Elderly
|b Reference Ranges and Biological Variations After Repeated Measurements /
|c by Hans-Peter Breuel.
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| 250 |
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|a 1st ed. 1996.
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| 260 |
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|a Berlin, Heidelberg :
|b Springer Berlin Heidelberg :
|b Imprint: Springer,
|c 1996.
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| 300 |
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|a VIII, 182 p. 2 illus.
|b online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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|a 1 Introduction -- 2 Theories of Aging -- 3 Changes in Body Functions, Pharmacokinetics, and Receptor Sensitivity with Age -- 3.1 Changes in Central Nervous System -- 3.2 Cardiovascular and Pulmonary Changes -- 3.3 Changes in Clinical Chemistry and Hematology -- 3.4 Changes in Pharmacokinetics -- 3.5 Changes in Receptor Sensitivity -- 4 Practical Aspects in Performing Clinical Trials in Elderly Subjects -- 4.1 Recruitment of Subjects -- 4.2 Performance of the Study -- 4.3 Safety Aspects -- 4.4 Sample Size -- 4.5 Compliance of Subjects with Medication and Study Regulations -- 5 Experimental Findings in Elderly Subjects -- 5.1 Method -- 5.2 Experimental Data -- 5.3 Consequences from Experimental Data in Healthy Subjects -- 6 Statistical Details -- 6.1 Blood Pressure -- 6.2 Ambulatory Blood Pressure Monitoring -- 6.3 ECG Times -- 6.4 Ambulatory ECG Monitoring -- 6.5 Spirometry (FEV1) -- 6.6 Clinical Chemistry -- 6.7 Hematology -- References.
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| 650 |
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|a Pharmacology.
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|a Internal medicine.
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|a Pharmacology/Toxicology.
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| 650 |
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|a Internal Medicine.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 856 |
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|u https://doi.org/10.1007/978-3-642-60998-5
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