Clinical Pharmacology in the Elderly Reference Ranges and Biological Variations After Repeated Measurements /
| Main Author: | |
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| Corporate Author: | |
| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
1996.
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| Edition: | 1st ed. 1996. |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-3-642-60998-5 |
Table of Contents:
- 1 Introduction
- 2 Theories of Aging
- 3 Changes in Body Functions, Pharmacokinetics, and Receptor Sensitivity with Age
- 3.1 Changes in Central Nervous System
- 3.2 Cardiovascular and Pulmonary Changes
- 3.3 Changes in Clinical Chemistry and Hematology
- 3.4 Changes in Pharmacokinetics
- 3.5 Changes in Receptor Sensitivity
- 4 Practical Aspects in Performing Clinical Trials in Elderly Subjects
- 4.1 Recruitment of Subjects
- 4.2 Performance of the Study
- 4.3 Safety Aspects
- 4.4 Sample Size
- 4.5 Compliance of Subjects with Medication and Study Regulations
- 5 Experimental Findings in Elderly Subjects
- 5.1 Method
- 5.2 Experimental Data
- 5.3 Consequences from Experimental Data in Healthy Subjects
- 6 Statistical Details
- 6.1 Blood Pressure
- 6.2 Ambulatory Blood Pressure Monitoring
- 6.3 ECG Times
- 6.4 Ambulatory ECG Monitoring
- 6.5 Spirometry (FEV1)
- 6.6 Clinical Chemistry
- 6.7 Hematology
- References.