Principles of Peptide Synthesis
| Autor principal: | |
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| Autor Corporativo: | |
| Formato: | eBook |
| Lenguaje: | English |
| Publicado: |
Berlin, Heidelberg :
Springer Berlin Heidelberg : Imprint: Springer,
1993.
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| Edición: | 2nd ed. 1993. |
| Colección: | Springer Lab Manuals
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| Materias: | |
| Acceso en línea: | https://doi.org/10.1007/978-3-642-78056-1 |
Tabla de Contenidos:
- I. Introduction
- References
- II. Activation and Coupling
- 1 Activation
- 2 Coupling
- 3 Coupling Methods
- References
- III. Reversible Blocking of Amino and Carboxyl Groups
- 1 General Aspects
- 2 Protection of the Carboxyl Group
- 3 Protection of the Amino Group
- References
- IV. Semipermanent Protection of Side Chain Functions
- 1 Carboxyl Groups of Aspartyl and Glutamyl Residues
- 2 Side Chain Amino Groups of Lysine and Ornithine
- 3 Hydroxyl Groups in Serine, Threonine and Tyrosine
- 4 The Sulfhydryl Group in Cysteine
- 5 The Guanidino Group of Arginine
- 6 Imidazole in Histidine
- 7 The Thioether in Methionine
- 8 The Indole Nitrogen in Tryptophan
- 9 The Carboxamide Groups in Asparagine and Glutamine
- References
- V. Side Reactions in Peptide Synthesis
- 1 Side Reactions Initiated by Proton Abstraction
- 2 Side Reactions Initiated by Protonation
- 3 Side Reactions Due to Overactivation
- 4 Side Reactions Related to Individual Amino Acid Residues
- References
- VI. Tactics and Strategy in Peptide Synthesis
- 1 Tactics
- 2 Strategies
- 3 Disulfide Bridges
- 4 Synthesis of Cyclic Peptides
- 5 Sequential Polypeptides
- 6 Partial Synthesis (Semisynthesis)
- References
- VII. Techniques for the Facilitation of Peptide Synthesis
- 1 Solid Phase Peptide Synthesis (SPPS)
- 2 Synthesis in Solution
- References
- VIII Recent Developments, New Trends
- 1 Formation of the Peptide Bond
- 2 Protecting Groups
- 3 Solid Phase Peptide Synthesis
- 4 Undesired Reactions in Peptide Synthesis
- 5 New Trends and Perspectives
- References.