Biochemistry and Molecular Biology of Antimicrobial Drug Action
| Main Author: | |
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| Corporate Author: | |
| Format: | eBook |
| Language: | English |
| Published: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
1998.
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| Edition: | 1st ed. 1998. |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-94-010-9127-5 |
Table of Contents:
- 1 The Development of Antimicrobial Agents Past, Present and Future
- 1.1 The social and economic importance of antimicrobial agents
- 1.2 An outline of the historical development of antimicrobial agents
- 1.3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds
- 1.4 Uncovering the molecular basis of antimicrobial action
- 1.5 Scope and layout of the present book
- 2 Vulnerable Shields - The Cell Walls of Bacteria and Fungi
- 2.1 Functions of the cell wall
- 2.2 Structure of the bacterial wall
- 2.3 Structure and biosynthesis of peptidoglycan
- 2.4 Antibiotics that inhibit peptidoglycan biosynthesis
- 2.5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria
- 2.6 The structure of the fungal cell wall
- 2.7 Inhibitors of the biosynthesis of the fungal cell wall
- 3 Antiseptics, Antibiotics and the Cell Membrane
- 3.1 Microbe killers: antiseptics and disinfectants
- 3.2 Polypeptide antibiotics
- 3.3 lonophoric antibiotics
- 3.4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols
- 4 Inhibitors of Nucleic Acid Synthesis
- 4.1 Compounds affecting the biosynthesis and utilization of nucleotide precursors
- 4.2 Inhibitors of nucleic acid biosynthesis at the polymerization stage
- 5 Inhibitors of Protein Biosynthesis
- 5.1 Ribosomes
- 5.2 Stages in protein biosynthesis
- 5.3 Puromycin
- 5.4 Inhibitors of aminoacyl-tRNA formation
- 5.5 Inhibitors of initiation and translation
- 5.6 Inhibitors of peptide bond formation and translocation
- 5.7 Nitrofurantoin - a ribosomal poison?
- 5.8 Effects of inhibitors of 70S ribosomes on eukaryotic cells
- 6 Antimicrobial Drugs with other Modes of Action
- 6.1 Antibacterial agents
- 6.2 A unique antifungal antibiotic - griseofulvin
- 6.3 Antiviral agents
- 6.4 Antiprotozoal agents
- 7 Penetrating the Defences: How Antimicrobial Drugs Reach Their Targets
- 7.1 Cellular permeability barriers to drug penetration
- 7.2 Multidrug efflux in bacteria
- 7.3 Examples of the uptake of antibacterial drugs
- 7.4 Uptake of antimicrobial drugs by eukaryotic pathogens
- 8 The Genetic Basis of Resistance to Antimicrobial Drugs
- 8.1 Mutations and the origins of drug-resistance genes
- 8.2 Gene mobility and transfer in bacterial drug resistance
- 8.3 Global regulators of drug resistance in Gram-negative bacteria
- 9 Biochemical Mechanisms of Resistance to Antimicrobial Drugs
- 9.1 Enzymic inactivation of drugs
- 9.2 Modification of drug targets
- 9.3 Drug efflux pumps
- 9.4 Other mechanisms of resistance
- 9.5 Drug resistance and the future of chemotherapy.